Preclinical Studies



Facilities

  • We have an Animal House duly registered under CPCSEA
  • We house the animals as per the norms/ recommendations of CPCSEA.
  • We breed the animals in-house as per our in-house requirements.
  • Our staff consists of enthusiastic and dedicated graduates well experienced in Animal experiments. We also have highly qualified professionals to provide guidance.
  • The animal house & animal experiments are monitored by Institutional Animal Ethics Committee (IAEC) as per the requirement of CPCSEA.

SDL has conducted Acute, Sub-Acute, Chronic & Reproductive Toxicity studies for most of its formulations

Acute Toxicity study conducted for following formulations

 

Sr.No.

 Formulation

Sr.No.

 Formulation

1

 Mahayograj Guggul

19

 Rasaraj Rasa

2

 Kanchanar Guggul

20

 Shwaskaschintamani Rasa

3

 Amrutadi Guggul

21

 Yogendra Rasa

4

 Panchatiktaghrit Guggul

22

 Makardhwaj Gutika

5

 Suvarna Bhasma

23

 Drakshovin Special

6

 Abhrak Bhasma (100 puti)

24

 Pushpadhanwa

7

 Praval Bhasma

25

 Articure Tablet (Solumiks)

8

 Loha Bhasma

26

 Triliv Tablet (Solumiks)

9

 Kantaloha Bhasma

27

 Afrodet Plus Capsule (Solumiks)

10

 Mandoor Bhasma

28

 Afrol Plus Capsule (Solumiks)

11

 Shouktik Bhasma

29

 Ashotone Tablet (Solumiks)

12

 Suvarnamakshik Bhasma

30

 Efiplus Capsule (Solumiks)

13

 Brihat Kasturi Bhairav Rasa

31

 Entostal Tablet (Solumiks)

14

 Chaturmukh Rasa

32

 Honicof Syrup (Solumiks)

15

 Jayamangal Rasa

33

 Myostaal Tablet (Solumiks)

16

 Sootikabharan Rasa

34

 Nirocil Tablet (Solumiks)

17

 Mahalaxmivilas Rasa

35

 Vimliv Tablet (Solumiks)

18

 Kumarkalyan Rasa

36

 Kofrid Syrup (Solumiks)

 

Chronic Toxicity Study conducted for following formulations

 

Sr.No

 Formulation

Sr.No.

 Formulation

1

 Brihatvatachintamani

7

 Tamra Bhasma

2

 Suvarnamalinivasant

8

 Vanga Bhasma

3

 Sootashekhar (Suvarnayukta)

9

 Trivanga Bhasma

4

 Vasantakusumakar

10

 Roupya Bhasma

5

 Suvarnaraj Vangeshwar

11

 Jasad Bhasma

6

 Naga Bhasma

12

 Kajjali

13

Pushpadhanwa


In addition to these studies we have conducted                               

  • Reproductive Toxicity study for Garbhapala Rasa.
  • Study on Pharmacokinetics and Retention of Mercury in Traditional Medicine. Study done in collaboration with Radiopharmaceuticals Department, Bhabha Atomic Research Centre (BARC), Mumbai.

Along with these, Our R & D department has carried out Pharmacological studies like

  1.  Anti-ulcer activity of Sootashekhar 
  2.  Anti-arrhythmic activity of Brihatvatachintamani 
  3.  Immunomodulatory activity of Suvarnamalinivasant 
  4.  Anti-inflammatory activity of Suvarnamalinivasant 
  5.  Anti-arthritic activity of Suvarnamalinivasant 
  6.  Immunomodulatory activity of SD 906 
  7.  Gastric Irritancy Index for SD 906 
  8.  Study of absorption of SD 906 
  9.  Gastric irritancy index of Guggul Kalpa products
  10.  Analgesic activity of Entostal (Solumiks)
  11.  Anti-spasmodic activity of Entostal (Solumiks)
  12.  Pharmacodynamic animal study involving Analgesic & Anti-arthritic activity of the test formulations (Oral route)
  13.  Pharmacodynamic animal study involving Analgesic & Anti-arthritic activity of the test formulations (Intraperitoneal route)

Pharmacodynamic animal study involving Analgesic & Anti-arthritic activity of the test formulations (Intraperitoneal route)

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